Sonntag, 9. August 2009

Pestizide und Parkinson - Studie belegt Zusammenhang

Einer neuen umweltmedizinischen Studie aus Kalifornien zufolge besteht ein direkter Zusammenhang zwischen der Einnahme von pestizidbelasteten Grundwasser und dem Auftreten der Parkinsonkrankheit.
Demzufolge erhöht insbesondere die Verunreinigung durch Methomyl, Chlorpyrifos und Propargite das Erkrankungsrisiko um bis zu 90%.
Alle 3 sind hochpotente Insektizide und Hemmer der Cholinesterasen bei Mensch und Tier.

Well Water Consumption and Parkinson’s Disease in Rural California
Nicole M. Gatto1, Myles Cockburn, Jeff Bronstein3, Angelika D. Manthripragada1, Beate Ritz
Department of Epidemiology, University of California Los Angeles
Department of Preventive Medicine, University of Southern California
Department of Neurology, University of California Los Angeles
Department of Environmental Health Sciences, University of California Los Angeles

doi: 10.1289/ehp.0900852 (available at
Online 31 July 2009


Introduction: Consumption of pesticide contaminated well water has been hypothesized to play
a role in Parkinson’s disease (PD), and several previous epidemiologic studies support this
hypothesis. Objectives: We investigated whether consumption of water from private wells
located in areas with documented historical pesticide use was associated with an increased risk
of PD. Methods: We employed a GIS-based model to estimate potential well water
contamination from agricultural pesticides, among 368 cases and 341 population controls
enrolled in the Parkinson’s Environment and Genes study. We separately examined six
pesticides (diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl) from among
26 chemicals selected for their potential to pollute groundwater or because they are of interest
for PD, and to which at least 10% of our population were exposed. Results: Cases were more
likely to have consumed private well water, and had consumed it on average 4.3 years longer
than controls (p=0.02). High levels of possible well water contamination with methomyl (OR =
1.67, 95%CI = 1.00, 2.78), chlorpyrifos (OR = 1.87, 95% CI = 1.05, 3.31) and propargite (OR =
1.92, 95% CI = 1.15, 3.20) resulted in ~70% - 90% increases in risk of PD. Adjusting for
ambient pesticide exposures only slightly attenuated these increases. Exposure to a higher
number of water soluble pesticides and organophosphate pesticides also increased the risk of
PD. Conclusion: Our study, the first to use agricultural pesticide application records, adds
evidence that consumption well water presumably contaminated with pesticides may play a role
in the etiology of PD.

Die ganze Studie:

hier gefunden:

Keine Kommentare: